Duardo was born in the Los Angeles neighborhood of Boyle Heights, just a short distance from Cal State LA, and he graduated from Franklin High School in Highland Park. He is credited with creating “Latino Pop” and was a pivotal figure in the Chicano art community. After graduating with a Master of Fine Arts at UCLA, Duardo returned to the Eastside and worked at the iconic Self Help Graphics, and then helped found Centro de Arte Público in Highland Park, which became a focal point of art and political activism. He later established Modern Multiples, a print studio that was integral to the growing downtown Los Angeles art scene.
Duardo utilized pop culture and political figures, featuring images of Che Guevara, Bob Dylan, Jimi Hendrix and Mao Tse-Tung, among others. He used serigraphy and a graphic sensibility to reflect his interest in capturing the energy of sub-cultures such as punk, rave and street art. As a master printmaker, Duardo produced for such acclaimed artists as Banksy, David Hockney, Shepard Fairey, Keith Haring and Gary Panter.